Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 123, Issue 42, Pages 10214-10220Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja011710n
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The tandem cyclohydrocarbonylative/CO insertion of alpha -imino alkynes employs CO, H-2, and catalytic quantities of zwitterionic rhodium complex (eta (6)-C6H5BPh3)Rh--(+)(1,5-COD) and triphenyl phosphite affording aldehyde substituted pyrrolinones in 67-82% yields. This unique transformation is readily applied to imino alkynes containing alkyl, alkoxyl, vinyl, and aryl substituents. The ability to prepare highly functionalized pyrrolinones makes this an attractive route to these important and versatile pharmaceuticals.
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