Journal
ONCOGENE
Volume 20, Issue 48, Pages 7098-7103Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1204898
Keywords
Rel; c-Rel; NF-kappa B; Bcl-2; v-Rel; malignant transformation
Funding
- NCI NIH HHS [CA47763] Funding Source: Medline
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Rel/NF-kappaB transcription factors control a variety of cellular processes, such as cell growth and apoptosis, that are relevant to oncogenesis, and mutations in genes encoding Rel/NF-kappaB transcription factors have been found in several human lymphoid cell cancers. In this study, we have used a sensitive cell outgrowth assay to demonstrate that wild-type human c-Rel can malignantly transform primary chicken spleen cells, and that transformation by c-Rel is accelerated by co-expression of Bcl-2. Full-length mouse c-Rel can also transform chicken spleen cells. These results are the first demonstration of a lymphoid cell malignant transforming ability for mammalian Rel/NF-kappaB transcription factors, and implicate c-Rel as a molecular target for cancer therapeutics.
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