Journal
NEUROSCIENCE LETTERS
Volume 312, Issue 3, Pages 180-182Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)02215-7
Keywords
neural stem cells; CD9; CD15; CD34; CD81 (TAPA-1); CD95 (Fas); GD(2) ganglioside; major histocompatibility complex
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Funding
- NEI NIH HHS [EY 09595] Funding Source: Medline
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Surface molecules play important roles in a wide range of cellular functions, yet little has been reported regarding the expression of such markers by neural stem cells. Here, multipotent human neural progenitor cells (hNPCs) were expanded as a monolayer in the presence of fibroblast/epidermal growth factor, harvested, labeled with monoclonal antibodies, and analyzed by flow cytometry. Positive markers included CD9, CD15, CD81, CD95 (Fas), GD(2) ganglioside, and major histocompatibility complex class I and beta2 microglobulin, as well as low levels of the hematopoietic stem cell marker CD34. Of these, mouse NPCs were positive for CD9, CD15, CD81, and GD(2) ganglioside. The markers reported here have been implicated in a wide range of cellular functions including proliferation, migration, differentiation, apoptosis, and immune recognition. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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