Late neurodevelopmental effects of early exposures to chemical contaminants: Reducing uncertainty in epidemiological studies

Early exposures to environmental chemicals are reliably associated with late neurotoxicities in children. However, substantial scatter of observations exists around the estimated dose-effect relationships. This variability has many potential sources, one of which is interindividual differences in susceptibility. Such differences imply that the long-term impacts of exposure will not the same for all individuals, but will vary depending on a variety of factors that might either aggravate or mitigate contaminant effects. These include co-exposures, genetic polymorphisms and characteristics of the social environment. The context dependence of contaminant effects has implications both for study designs and analytical approaches. In addition, a systems approach to understanding the associations among contaminant exposures, covariates and health outcomes is necessary.