Journal
TETRAHEDRON LETTERS
Volume 42, Issue 44, Pages 7863-7865Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)01658-6
Keywords
HPA-12; a novel inhibitor of ceramide trafficking Mannich-type reaction; asymmetric reaction
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A novel inhibitor of ceramide trafficking, (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide (HPA-12), has been synthesized using a chiral zirconium-catalyzed asymmetric Mannich-type reaction as a key-step. (C) 2001 Elsevier Science Ltd. All rights reserved.
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