Journal
NEUROREPORT
Volume 12, Issue 15, Pages 3183-3188Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200110290-00008
Keywords
apoptosis; Brn-3a; central nervous system; neuronal survival; POU domain
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Funding
- Medical Research Council [G9901318] Funding Source: Medline
- Medical Research Council [G9901318] Funding Source: researchfish
- MRC [G9901318] Funding Source: UKRI
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We have demonstrated previously that exogenously expressed Brn-3a is capable of protecting neurons of the peripheral nervous system against apoptosis. In these previous studies Brn-3a showed a degree of neuronal sub-type specificity, in that while it could promote survival in NGF-dependent sensory neurons, no effect was observed in NGF-dependent neurons of the sympathetic nervous system. In this report, we show that Brn-3a delivered using a herpes simplex virus is capable of protecting cultures of rat cerebrocortical neurons of the central nervous system against two types of cell death stimuli, including glutamate neurotoxicity. Hence the protective effect of Brn-3a is not confined to neurons of the peripheral nervous system but can also occur in neurons of the CNS. NeuroReport 12:3183-3188 (C) 2001 Lippincott Williams & Wilkins.
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