Journal
CANCER LETTERS
Volume 172, Issue 2, Pages 187-192Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(01)00651-6
Keywords
tongue carcinoma; early recurrence; cyclin D1; fluorescence in situ hybridization
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Amplification of CCND1 was studied in 23 tongue carcinoma patients by fluorescence in situ hybridization (FISH) using a paraffin embedded specimen. All the patients received complete resection of the primary site with or without neck dissection. CCND1 amplification was positive in 1.3 (56.5%) out of 23 cases. Correlations between CCND1 amplification and histological grading, T category, N category, and Stages were not significant. The 5-year disease-free survival rate, which was 23.1% for CCND1 amplification positive patients and 80.0% for negative patients, was significantly better for the CCND1 amplification negative patients (P = 0.0070). Nine patients were examined by dual-color FISH with the probe for centromere of chromosome 11 and 11q13. In five patients, who had positive amplification for CCND1, cell numbers with a larger number of signals for 11q13 than the centromere of chromosome I I were significantly higher than those of CCND1 amplification negative patients (P = 0.013). This indicates that amplification of 11q13 occurs more frequently than aberration of chromosome I I in CCND1 amplification positive patients. From these results, the amplification of CCND1 is a key factor in predicting the aggressiveness of tongue cancer. Furthermore, FISH proved to be a useful method for such evaluation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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