Journal
NATURE IMMUNOLOGY
Volume 2, Issue 11, Pages 1067-1076Publisher
NATURE AMERICA INC
DOI: 10.1038/ni727
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Funding
- NIAID NIH HHS [AI-46578] Funding Source: Medline
- NIAMS NIH HHS [AR-35506] Funding Source: Medline
- NIDDK NIH HHS [DK32520] Funding Source: Medline
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A potent role for memory CD8(+) T cells in heterologous immunity was shown with a respiratory mucosal model of viral infection. Memory CD8(+) T cells generated after lymphocytic choriomeningitis virus (LCMV) infection were functionally activated in vivo to produce interferon-gamma (IFN-gamma) during acute infection with vaccinia virus (VV). Some of these antigen-specific memory cells selectively expanded in number, which resulted in modulation of the original LCMV-specific T cell repertoire. In addition, there was an organ-selective compartmental redistribution of these LCMV-specific T cells during VV infection. The presence of these LCMV-specific memory T cells correlated with enhanced VV clearance, decreased mortality and marked changes in lung immunopathology. Thus, the participation of pre-existing memory T cells specific to unrelated agents can alter the dynamics of mucosal immunity and disease course in response to a pathogen.
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