Journal
INFECTION AND IMMUNITY
Volume 69, Issue 11, Pages 7169-7172Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.69.11.7169-7172.2001
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Funding
- NIAID NIH HHS [R37 AI022159, AI22159, R01 AI022159] Funding Source: Medline
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Host susceptibility to lipopolysaccharide (LPS) is correlated with the levels of circulating tumor necrosis factor alpha (TNF-alpha) that develop in response to circulating LPS. Mice are resistant, relative to rabbits, to the lethal effects of LPS. This study indicates that mice and rabbits are equally sensitive to the lethal effects of circulating TNF-alpha but that mice are more resistant than rabbits to the induction of circulating TNF-alpha by LPS.
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