Journal
NEUROPHARMACOLOGY
Volume 41, Issue 6, Pages 693-699Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0028-3908(01)00128-9
Keywords
long-term potentiation; N-methyl-D-aspartate; hippocampus; neuronal culture
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Funding
- Medical Research Council [G9629038] Funding Source: Medline
- Medical Research Council [G9629038] Funding Source: researchfish
- MRC [G9629038] Funding Source: UKRI
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Long-term potentiation (LTP) of synaptic transmission is under intense investigation. It is believed that the mechanisms involved in its induction and expression are critically involved in synaptic processes that are important for teaming and memory and other physiological functions. A reliable means of inducing LTP in dissociated cultured neurones would facilitate investigations into the molecular basis of LTP but has been hard to achieve. Here we report a mechanism for inducing LTP in postnatal dissociated hippocampal neurones using transient depolarisation. This form of LTP is prevented by NMDA receptor antagonists and by chelating Call in the postsynaptic neurone. It is manifest primarily as an increase in the frequency of mEPSCs. (C) 2001 Published by Elsevier Science Ltd.
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