Journal
PHYTOMEDICINE
Volume 8, Issue 6, Pages 477-480Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1078/S0944-7113(04)70069-0
Keywords
antiviral activity; virucidal; HEp-2 cells; acyclovir-resistant HSV-1; flavonoids; Vitex polygama; Verbenaceae
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Extracts and fractions rich in flavonoids from fruits and leaves of Vitex polygama Cham. (Verbenaceae) were tested against acyclovir-resistant herpes simplex virus type 1 (ACV(R)-HSV-1). Both fruit and leaf extracts exhibited a dose-dependent antiviral activity. The extract from the leaves showed intracellular antiviral activity while the extract from the fruits had virucidal effect. A fraction from the ethyl actetate extract of the leaves inhibited virus propagation by blocking HEp-2 cell receptors.
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