Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 45, Issue 11, Pages 3216-3219Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.45.11.3216-3219.2001
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Funding
- NIDCR NIH HHS [1RO1 DE13334, P30 DE10126, R01 DE013334] Funding Source: Medline
- NIEHS NIH HHS [P30 ES010126] Funding Source: Medline
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The effects of cathelicidins against oral bacteria and clinically important oral yeasts are not known. We tested the susceptibilities of Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus sanguis, Candida krusei, Candida tropicalis and Candida albicans to the following cathelicidins: FALL39, SMAP29, and CAP18. SMAP29 and CAP18 were antimicrobial, whereas FALL39 did not exhibit antimicrobial activity. Future studies are needed to determine the potential use of these antimicrobial peptides in prevention and treatment of oral infections.
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