Journal
NATURE NEUROSCIENCE
Volume 4, Issue 11, Pages 1108-1115Publisher
NATURE AMERICA INC
DOI: 10.1038/nn743
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Funding
- NCI NIH HHS [SCOR-HL-60287] Funding Source: Medline
- NHLBI NIH HHS [R01-HL-59649] Funding Source: Medline
- NIMH NIH HHS [R01 MH067774] Funding Source: Medline
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In the fruit fly, Drosophila melanogaster, rest shares features with mammalian sleep, including prolonged immobility, decreased sensory responsiveness and a homeostatic rebound after deprivation. To understand the molecular regulation of sleep-like rest, we investigated the involvement of a candidate gene, cAMP response-element binding protein (CREB). The duration of rest was inversely related to cAMP signaling and CREB activity. Acutely blocking CREB activity in transgenic flies did not affect the clock, but increased rest rebound. CREB mutants also had a prolonged and increased homeostatic rebound. In wild types, in vivo CREB activity increased after rest deprivation and remained elevated for a 72-hour recovery period. These data indicate that cAMP signaling has a non-circadian role in waking and rest homeostasis in Drosophila.
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