Journal
PHARMACOGENETICS
Volume 11, Issue 8, Pages 687-698Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00008571-200111000-00007
Keywords
CYP2A; CYP2B; CYP2F; CYP2G; CYP2S; CYP2T; cytochrome P450; gene duplication; gene family
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The cytochrome P450 superfamily of mixed-function oxygenases has been extensively studied due to its many critical metabolic roles, and also because it is a fascinating example of gene family evolution. The cluster of genes on human chromosome 19 from the CYP2A, 2B, and 2F subfamilies has been previously described as having a complex organization and many pseudogenes. We describe the discovery of genes from three more CYP2 subfamilies inside the cluster, and assemble a complete map of the region. We comprehensively review the organization, structure, and expression of genes from all six subfamilies. A general hypothesis for the evolution of this complex gene cluster is also presented. Pharmacogenetics 11:687-698 (C) 2001 Lippincott Williams & Wilkins.
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