Journal
EXPERIMENTAL NEUROLOGY
Volume 172, Issue 1, Pages 235-243Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/exnr.2001.7792
Keywords
oleamide; sleep; body temperature; motor activity; blood pressure
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Funding
- NIDA NIH HHS [DA08301] Funding Source: Medline
- NIMH NIH HHS [MH58542] Funding Source: Medline
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Oleamide (cis-9,10-octadecenoamide) is a brain lipid that has recently been isolated from the cerebral fluid of sleep-deprived cats. Intracerebroventricular and intraperitoneal administration of oleamide induces sleep in rats. However, it is unclear whether oleamide's hypnogenic effects are mediated, in part, by its actions on blood pressure and core body temperature. Here we show that systemic administration of oleamide (10 and 20 mg/kg) in rats increased slow-wave sleep 2, without affecting blood pressure and heart rate. In addition, oleamide decreased body temperature and locomotor activity in a dose-dependent manner. These latter effects were not correlated in time with the observed increases in slow-wave sleep. These data suggest that the hypnogenic effects of oleamide are not related to changes in blood pressure, heart rate, or body temperature. (C) 2001 Academic Press.
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