Journal
EUROPEAN JOURNAL OF CANCER
Volume 37, Issue 16, Pages 2064-2072Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0959-8049(01)00225-8
Keywords
angiogenesis; brain tumour; medulloblastoma; vascular endothelial growth factor; basic fibroblast growth factor; angiopoetin; transforming growth factor-alpha; platelet-derived endothelial growth factor
Categories
Funding
- NINDS NIH HHS [P01-NS34514] Funding Source: Medline
Ask authors/readers for more resources
Primitive neuroectodermal brain tumours (PNET) including medulloblastomas (PNET/MB) are the most common malignant brain tumours of childhood. Similar to many other brain tumours, PNET/MB often show marked neovascularisation. To determine which angiogenic factors contribute to PNET/MB angiogenesis, we examined the expression of eight angiogenic factors (vascular endothelial growth factors ( VEGF, VEGF-B. VEGF-C), basic fibroblast growth factor (bFGF), angiopoetins (Ang-1, Ang-2), transforming growth factor (TGF-alpha). and platelet-derived endothelial growth factor (PDGF-A)) by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in six PNET cell lines and 28 primary PNET/MB. Expression levels of angiogenic factors were compared with microvessel density. TrkC mRNA expression. clinical variables and survival outcomes. Our results indicate that all PNET/MB tested produce a wide range of angiogenic factors that are, individually or together, likely to play a direct role in PNET/MB tumour growth. This suggests that anti-angiogenesis approaches targeting VEGF alone may be insufficient in PNET/MB. (C) 2001 Elsevier Science Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available