Journal
TUMOR BIOLOGY
Volume 22, Issue 6, Pages 345-347Publisher
KARGER
DOI: 10.1159/000050637
Keywords
CA 125; immunoassay; cloning; OC 125; mucin; gene sequence; tumor marker
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CA 125, a high-molecular-weight mucin, was first defined in 1981 by the monoclonal antibody OC125. Until recently, it has defied many attempts to purify it from a variety of sources, although many research groups have successfully raised antibodies that bind to CA 125. Nevertheless, CA 125 has demonstrated its considerable value as a marker in monitoring patients with ovarian cancer. This year, two research groups have succeeded in cloning the high-molecular-weight mucin CA 125. Their findings are summarized and the significance discussed in light of existing data from the human genome. Copyright (C) 2001 S. Karger AG, Basel.
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