Journal
MICROBES AND INFECTION
Volume 3, Issue 13, Pages 1167-1171Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1286-4579(01)01477-0
Keywords
T lymphocytes; B lymphocytes; innate immunity; adaptive immunity; suppressor T cells
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The immune system is made up of sets of interacting cells. The first to respond in an cases are the antigen-presenting cells (APCs), which are equipped with receptors for microbial patterns. Engagement of these receptors induces co-stimulatory molecules on the surface of the APCs, and allows it to stimulate potent CD4 T-cell responses, and also CD8 T-cell responses. This in turn leads to B-cell-derived antibody responses. The entire response is controlled by suppressor T cells, as predicted many years ago by Richard Gershon. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
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