Journal
NEUROPSYCHOPHARMACOLOGY
Volume 25, Issue -, Pages S45-S49Publisher
NATURE PUBLISHING GROUP
DOI: 10.1016/S0893-133X(01)00338-4
Keywords
sleep; immunity; cytokines; major depression; alcoholism
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Funding
- NCRR NIH HHS [M01 RR00827] Funding Source: Medline
- NIAAA NIH HHS [AA10215] Funding Source: Medline
- NIMH NIH HHS [2P30-MH30914] Funding Source: Medline
- PHS HHS [5T32-18399] Funding Source: Medline
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The specific functions of sleep are now known, although sleep is commonly considered a restorative process that is important for the proper functioning of the immune system. Severity of disordered sleep in depressed and alcoholic subjects correlates with declines in natural and cellular immunity and is associated with alterations in the complex cytokine network. Despite evidence that sleep and sleep loss have effects on immune processes and nocturnal secretion of cytokines, the physiological significance of these immune changes is not known. Moreover, in view of basic evidence of a reciprocal interaction between sleep and cytokines, further research is needed to understand whether alterations in cytokines contribute to disordered sleep. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.
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