Journal
PEST MANAGEMENT SCIENCE
Volume 57, Issue 11, Pages 1000-1006Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/ps.382
Keywords
anthelmintic; cyclic octadepsipeptide; PF1022A; thionated depsipeptide; Haemonchus contortus; Trichostrongylus colubriformis
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The tetra- and mono-thionated cyclic octadepsipeptides represent novel cyclic octadepsipeptide derivatives with broad-spectrum activity against parasitic nematodes in mice and sheep. Some of these show better activity than the potent natural anthelmintic cyclic octadepsipeptide PF1022A against Hymenolepis nana, Heterakis spumosa and Trichinella spiralis larvae in mice. In particular, they show improved efficacy against Haemonchus contortus and Trichostrongylus colubriformis in sheep compared with PF1022A. Here we report on two different and simple synthetic pathways for this new class of thionated cyclic octadepsipeptides. (C) 2001 Society of Chemical Industry
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