Journal
EUROPEAN JOURNAL OF BIOCHEMISTRY
Volume 268, Issue 22, Pages 5977-5980Publisher
WILEY
DOI: 10.1046/j.0014-2956.2001.02546.x
Keywords
renal cell carcinoma (RCC); 2D-gel electrophoresis; kidney; proteome; enzyme alteration
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To identify tumour-related enzyme alterations we have used 2D-gels to analyse the proteome from dissected malignant and benign kidney areas from patients with clear-cell-type renal carcinoma. The expression of 12 proteins was diminished in tumour. Four proteins were characterized by mass spectrometry and were identified as enoyl-CoA hydratase, alpha -glycerol-3-phosphate dehydrogenase, aldehyde dehydrogenase 1 and aminoacylase-1.
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