Journal
NATURE REVIEWS GENETICS
Volume 2, Issue 11, Pages 846-857Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35098564
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- NEI NIH HHS [F32 EY006763] Funding Source: Medline
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The near-catholic conservation of paired box gene 6 (Pax6) and its supporting cast of retinal determination genes throughout the animal kingdom has sparked a scientific war over the evolutionary origins of the eye. The battle pits those who support a polyphyletic history for the eye against those who argue for a common ancestor for all 'seeing' animals. Recent papers have shed light on how eyes in both vertebrates and invertebrates are patterned. New insights into the roles that signal-transduction cascades might have in determining the Drosophila melanogaster eye indicate that, like many developmental processes, eye specification is an inductive process.
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