Journal
ANESTHESIA AND ANALGESIA
Volume 93, Issue 5, Pages 1240-1245Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00000539-200111000-00040
Keywords
-
Categories
Funding
- NIGMS NIH HHS [GM 52387] Funding Source: Medline
Ask authors/readers for more resources
Some local anesthetics (LA), in concentrations present in blood during IV or epidural infusion, inhibit thrombus formation in the postoperative period. Studies on thromboxane A(2) (TXA(2)) signaling in a recombinant model suggest that interference with TXA(2)-induced platelet aggregation may explain, in part, the antithrombotic actions of epidural analgesia and IV LA infusion. In this study we investigated. the effects of clinically used LAs (lidocaine, ropivacaine, and bupivacaine) on TXA(2)-induced early platelet aggregation (1-5 s) by using quenched-flow and optical aggregometry. Our findings demonstrate that the LAs tested seem to have only a limited ability to inhibit TXA(2)- induced platelet aggregation assessed at early times (1-5 s). Therefore, the clinical effects of LAs on thrombi formation are unlikely to be explained by this manner alone. At large LA concentrations, moderate effects were obtained. Prolonged incubation with LA did not significantly increase effectiveness, and the lack of an effect could not be explained by generation of secondary mediators. The results were independent of the anesthetic studied. Local anesthetic effects on TXA(2)-induced early platelet aggregation (1-5 s) are unlikely to play a major role in the clinically observed antithrombotic effects of local anesthetics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available