Journal
JOURNAL OF VIROLOGY
Volume 75, Issue 22, Pages 11218-11221Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.22.11218-11221.2001
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Funding
- NIAID NIH HHS [R37 AI033456, P01 AI042257, P01-AI42257, R37-AI33456] Funding Source: Medline
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Several herpesviruses encode Fc receptors that may play a role in preventing antibody-mediated clearance of the virus in vivo. Human cytomegalovirus (HCMV) induces an Fc-binding activity in cells upon infection, but the gene that encodes this Fc-binding protein has not been identified. Here, we demonstrate that the HCMV AD169 open reading frame TRL11 and its identical copy, IRL11, encode a type I membrane glycoprotein that possesses IgG Fc-binding capabilities.
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