Journal
CURRENT OPINION IN RHEUMATOLOGY
Volume 13, Issue 6, Pages 483-487Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002281-200111000-00005
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- NHLBI NIH HHS [HL59878] Funding Source: Medline
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Over the past year, considerable progress has been made in our understanding of biologic actions by which tumor necrosis factor-alpha (TNF-alpha) may influence skeletal muscle metabolism. Reports published during this period highlighted three general actions with metabolic consequences: accelerated catabolism (protein loss, insulin resistance), contractile dysfunction, and disruption of myogenesis. Recent research also indicates that skeletal muscle myocytes synthesize TNF-alpha and that the cytokine functions as an endogenous mediator of muscle adaptation via autocrine/paracrine effects. These advances demonstrate the fundamental importance of TNF-alpha effects on skeletal muscle myocytes and provide a focus for future studies of intracellular mechanism. Curr Opin Rheumatol 2001, 13:483-487 (C) 2001 Lippincott Williams & Wilkins, Inc.
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