Journal
GENES AND IMMUNITY
Volume 2, Issue 7, Pages 411-414Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.gene.6363797
Keywords
ethnic groups; malarial immunity; interleukin-4; polymorphism
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The Fulani are less clinically susceptible and more immunologically responsive to malaria than neighbouring ethnic groups. Here we report that anti-malarial antibody levels show a wide distribution amongst the Fulani themselves, raising the possibility that quantitative analysis within the Fulani may be an efficient way of screening for important genetic factors. The Th2 cytokine interleukin-4 is an obvious candidate: in Fulani, the IL4-524 T allele is at high frequency and is associated with elevated antibody levels against malaria antigens. These data highlight the possibility of combining inter- and intra-ethnic comparisons to characterize critical determinants of malarial immunity in a natural setting.
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