Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 24, Issue 11, Pages 1286-1289Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.24.1286
Keywords
steroidal saponin; cytotoxic activity; HL-60 cell; structure-activity relationship
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We have systematically examined the cytotoxic activities of the steroidal saponins mainly isolated from the Liliaceae plants against HL-60 human promyelocytic leukemia cells and found several structure-activity relationships. Some steroidal saponins evaluated in the assay system showed considerable cytotoxic activities, which were almost as potent as that of etoposide used as a positive control. The activities were found to be sensitive to the monosaccharides constituting the sugar moieties and their sequences, as well as to the structures of the aglycons.
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