Journal
DEVELOPMENTAL CELL
Volume 1, Issue 5, Pages 655-665Publisher
CELL PRESS
DOI: 10.1016/S1534-5807(01)00069-7
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Funding
- NICHD NIH HHS [R37 HD21502-15, R37 HD021502-15] Funding Source: Medline
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Evidence is presented for a new pathway participating in anterior neural development. It was found that IGF binding protein 5 (IGFBP-5), as well as three IGFs expressed in early embryos, promoted anterior development by increasing the head region at the expense of the trunk in mRNA-injected Xenopus embryos. A secreted dominant-negative type I IGF receptor (DN-IGFR) had the opposite effect. IGF mRNAs led to the induction of ectopic eyes and ectopic head-like structures containing brain tissue. In ectodermal explants, IGF signals induced anterior neural markers in the absence of mesoderm formation and DN-IGFR inhibited neural induction by the BMP antagonist Chordin. Thus, active IGF signals appear to be both required and sufficient for anterior neural induction in Xenopus.
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