Journal
JOURNAL OF DENTAL RESEARCH
Volume 80, Issue 11, Pages 1968-1973Publisher
INT AMER ASSOC DENTAL RESEARCHI A D R/A A D R
DOI: 10.1177/00220345010800110401
Keywords
tooth specification and development; bone morphogenetic protein (Bmp) family member signaling; activin-like-kinase (Alk) receptors; bone morphogenetic proteins (BMPs); epithelial-mesenchymal cell interactions
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Funding
- NIDCR NIH HHS [DE12024, DE05736, DE12076] Funding Source: Medline
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We have recently identified, in zebrafish, a novel type I receptor of the TGFbeta family, alk8, that participates in Bmp signaling pathways to mediate early dorsoventral patterning of neurectodermal and mesendodermal tissues. Since Bmps play significant roles in tooth specification, initiation, and differentiation, we hypothesized that alk-8 may play a role in directing the Bmp-mediated epithelial mesenchymal cell interactions regulating tooth development. Immunohistochemical analysis demonstrates that Alk-8 is expressed in developing zebrafish and mouse teeth. Examination of tooth development in zebrafish with disrupted alk8 signaling revealed specific defects in tooth development. Ectopic expression of constitutively active Alk8 results in the formation of elongated tooth structures, while expression of dominant-negative Alk8 results in arrested tooth development at the bud stage. These results are consistent with the established requirements for Bmp signaling in tooth development and demonstrate that Alk8 is a key regulator of tooth development.
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