Journal
TRENDS IN CELL BIOLOGY
Volume 11, Issue 11, Pages S52-S59Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0962-8924(01)02149-3
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The establishment of connections between biochemical defects and clinical disease is a major goal of modern molecular genetics. In this review, we examine the current literature that relates defects in the two major DNA double-strand-break repair pathways - homologous recombination and nonhomologous end-joining - with the development of human tumors. Although definitive proof has yet to be obtained, the current literature is highly suggestive of such a link.
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