Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 22, Issue 11, Pages 565-572Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0165-6147(00)01805-8
Keywords
-
Categories
Ask authors/readers for more resources
Cannabis (marijuana) is not only a frequently abused drug but also has the potential for the development of useful agents for the treatment of emesis, anorexia. and multiple sclerosis. In this article, the effects of modulation of transmitter release by cannabinoids. in both the CNS and the PNS of various species, including humans, will be discussed. Cannabinoids inhibit neurotransmitter release via specific presynaptic cannabinoid CB1 receptors. Studies using either the CB1 receptor antagonist and inverse agonist SR141716 or CB1-receptor-deficient mice suggest that numerous presynaptic cannabinoid receptors are tonically activated by endogenous cannabinoids and/or are constitutively active. CB1-receptor-mediated inhibition of transmitter release might explain, for example, reinforcing properties and memory impairment caused by cannabinoids.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available