Journal
AUTOPHAGY
Volume 14, Issue 11, Pages 1847-1849Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2018.1522884
Keywords
AIM: ankyrins; autophagy; GABARAP; LC3; LIR
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Funding
- National Institute of General Medical Sciences [GM053396]
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The Atg8/LC3/GABARAP family of proteins binds its physiological binding partners, which function in macroautophagy (hereafter autophagy), via recognition of their short linear motif, also known as the LC3-interactiong region (LIR) or Atg8-interacting motif (AIM). The AIM/LIR motif, with the consensus sequence [W/F/Y]xx[L/I/V], utilizes the aromatic and hydrophobic residues that bind on the surface of Atg8/LC3/GABARAP. Despite modest binding affinity, this interaction is essential for efficient autophagy. Here we highlight the recent paper by Li and collaborators who discovered the structural basis for a much stronger interaction between the LIR motif-containing peptides and LC3/GABARAP. Moreover, they showed that these peptides are potent and selective inhibitors of autophagy in cultured cells and in C. elegans.
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