Journal
AUTOPHAGY
Volume 10, Issue 8, Pages 1470-1471Publisher
LANDES BIOSCIENCE
DOI: 10.4161/auto.29468
Keywords
curvature; Atg3; lipidation; LC3; phosphatidylethanolamine
Categories
Funding
- NIGMS NIH HHS [R01 GM100930] Funding Source: Medline
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The phagophore membrane is highly curved along the rim of the open cup, suggesting that the molecular mechanisms governing its formation and growth could rely on membrane curvature-dependent events. To this end, we recently reported that lipidation of the LC3 protein family is facilitated on highly curved membranes in vitro. We further showed that the conjugating enzyme ATG3 contains an amphipathic helix that is responsible for this membrane curvature dependency, and that the maintenance of this amphipathic structure is essential for ATG3 function in vivo.
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