Journal
AUTOPHAGY
Volume 10, Issue 11, Pages 2079-2081Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.34451
Keywords
autophagosomes; axonal transport; dynactin; dynein; JIP1; kinesin; LC3; LIR; MKP1; motor regulation
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Funding
- NIGMS NIH HHS [R01GM48661, R01 GM048661, T32GM7517, T32 GM007517] Funding Source: Medline
- NINDS NIH HHS [F31NS73262, F31 NS073262] Funding Source: Medline
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Autophagy is a spatially regulated process in axons; autophagosomes form preferentially in the distal axon tip then move actively and processively toward the cell body. Despite the primarily unidirectional transport observed in live-cell imaging experiments, both anterograde-directed KIF5/kinesin-1 motors and retrograde-directed dynein motors are tightly associated with axonal autophagosomes. Here, we discuss our recent work identifying the scaffolding protein MAPK8IP1/JIP1 (mitogen-activated protein kinase 8 interacting protein 1) as a key regulator of autophagosome transport in neurons. MAPK8IP1 tightly coordinates motor activity to ensure the fidelity of retrograde autophagosome transport in the axon.
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