Journal
AUTOPHAGY
Volume 10, Issue 10, Pages 1866-1867Publisher
LANDES BIOSCIENCE
DOI: 10.4161/auto.32170
Keywords
caspase; Dcp-1; sesB; adenine nucleotide translocase; mitochondria; autophagy; ATP; mitochondrial dynamics; ovary
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Funding
- Canadian Institutes of Health Research [MOP78882] Funding Source: Medline
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It has become evident that caspases function in nonapoptotic cellular processes in addition to the canonical role for caspases in apoptotic cell death. We recently demonstrated that the Drosophila effector caspase Dcp-1 localizes to the mitochondria and positively regulates starvation-induced autophagic flux during mid-oogenesis. Loss of Dcp-1 leads to elongation of the mitochondrial network, increased levels of the adenine nucleotide translocase sesB, increased ATP levels, and a reduction in autophagy. We found that sesB is a negative regulator of autophagic flux, and Dcp-1 interacts with sesB in a nonproteolytic manner to regulate its stability, uncovering a novel mechanism of mitochondrial associated, caspase-mediated regulation of autophagy in vivo.
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