Journal
AUTOPHAGY
Volume 10, Issue 5, Pages 936-937Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.28529
Keywords
Arabidopsis thaliana; glyoxysome leaf peroxisome; hydrogen peroxide; peroxisome; peroxisome transition; pexophagy
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Funding
- Grants-in-Aid for Scientific Research [22120007, 26440157, 26111523, 25440146] Funding Source: KAKEN
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In photosynthetic cells, a large amount of hydrogen peroxide is produced in peroxisomes through photorespiration, which is a metabolic pathway related to photosynthesis. Hydrogen peroxide, a reactive oxygen species, oxidizes peroxisomal proteins and membrane lipids, resulting in a decrease in peroxisomal quality. We demonstrate that the autophagic system is responsible for the elimination of oxidized peroxisomes in plant. We isolated Arabidopsis mutants that accumulated oxidized peroxisomes, which formed large aggregates. We revealed that these mutants were defective in autophagy-related (ATG) genes and that the aggregated peroxisomes were selectively targeted by the autophagic machinery. These findings suggest that autophagy plays an important role in the quality control of peroxisomes by the selective degradation of oxidized peroxisomes. In addition, the results suggest that autophagy is also responsible for the functional transition of glyoxysomes to leaf peroxisomes.
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