Journal
AUTOPHAGY
Volume 9, Issue 8, Pages 1167-1171Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.24880
Keywords
LAMP2; LAMP-2; LAMP2C; LAMP-2C; autophagy; RNA; RNautophagy; DNA; DNautophagy
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Funding
- Japan Society for the Promotion of Science [24680038]
- Ministry of Health, Labour, and Welfare of Japan [22790838, 21-9, 23-1, 24-11]
- Grants-in-Aid for Scientific Research [22790838, 23590244, 24680038] Funding Source: KAKEN
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Lysosomes contain various hydrolases that can degrade proteins, lipids, nucleic acids and carbohydrates. We recently discovered RNautophagy, an autophagic pathway in which RNA is directly taken up by lysosomes and degraded. A lysosomal membrane protein, LAMP2C, a splice variant of LAMP2, binds to RNA and acts as a receptor for this pathway. In the present study, we show that DNA is also directly taken up by lysosomes and degraded. Like RNautophagy, this autophagic pathway, which we term DNautophagy, is dependent on ATP. The cytosolic sequence of LAMP2C also directly interacts with DNA, and LAMP2C functions as a receptor for DNautophagy, in addition to RNautophagy. Similarly to RNA, DNA binds to the cytosolic sequences of fly and nematode LAMP orthologs. Together with the findings of our previous study, our present findings suggest that RNautophagy and DNautophagy are evolutionarily conserved systems in Metazoa.
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