Journal
AUTOPHAGY
Volume 9, Issue 11, Pages 1902-1903Publisher
LANDES BIOSCIENCE
DOI: 10.4161/auto.26168
Keywords
autophagy; BCL2; heart failure; MCL1; mitochondria
Categories
Funding
- NHLBI NIH HHS [R01 HL087023, R01HL087023, T32 HL007444, R01 HL101217, R01HL101217] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007198] Funding Source: Medline
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MCL1 (myeloid cell leukemia sequence 1 [BCL2-related]) is an anti-apoptotic BCL2 family protein that is upregulated in several human cancers. In malignancies, overexpression of MCL1 promotes cell survival and confers chemotherapeutic resistance. MCL1 is also highly expressed in normal myocardium, but the functional importance of MCL1 in myocytes has not been explored. We recently discovered that MCL1 plays an essential role in myocardial homeostasis and autophagy. Here, we discuss how loss of MCL1 in the adult mouse heart leads to mitochondrial dysfunction, impaired autophagy and development of heart failure.
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