Journal
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Volume 281, Issue 5, Pages E1088-E1094Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.2001.281.5.E1088
Keywords
cell proliferation; cell differentiation; fibroblast growth factors; interleukin-3
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In this study, the effect of thyroid hormone (triiodothyronine, T-3) on the secretion of mitogenic growth factors in astrocytes and C6 glioma cells was examined. The proliferating activity of T-3 could be due, at least in part, to the astrocyte secretion of acidic and basic fibroblast growth factor (aFGF and bFGF), tumor necrosis factor-beta, and transforming growth factor-beta. In contrast, the conditioned medium (CM) of T-3-treated C6 cells was mitogenic to this cell line only after hyaluronidase digestion, suggesting the impairment of growth factor mitogenic activity by hyaluronic acid. Furthermore, the presence of bFGF was significantly greater in the CM of both T-3-treated astrocytes and T-3-treated C6 cells than in the corresponding control CM. These data show that T-3 induces cerebellar astrocytes to secrete mitogenic growth factors, predominantly bFGF, that could influence astrocyte and neuronal proliferation via autocrine and paracrine pathways.
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