Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 22, Issue 11, Pages 580-586Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0165-6147(00)01809-5
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Funding
- NIGMS NIH HHS [GM63496] Funding Source: Medline
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Three isoforms of the inositol (1,4,5)-trisphosphate [Ins(1,4,5)P-3] receptor have been identified. Each receptor isoform has been functionally characterized using many different techniques. Although these receptor isoforms possess high homology, interesting differences in their Ca2+ dependence, Ins(1,4,5)P-3 sensitivity and subcellular distribution exist, implying distinct cellular roles. Indeed, interplay among the isoforms might be necessary for a cell to control spatial and temporal aspects of cytosolic Ca2+ signals, which are important for many cellular processes. In this review isoform-specific functions, primarily at the single-channel level, will be highlighted and these properties will be correlated with Ca2+ signals in intact cells.
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