Journal
AUTOPHAGY
Volume 9, Issue 3, Pages 403-409Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.23002
Keywords
LAMP; LAMP2; LAMP-2; LAMP2C; LAMP-2C; autophagy; RNA; RNautophagy
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Funding
- Grants-in-Aid for Scientific Research [24680038, 23590244] Funding Source: KAKEN
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Regulated degradation of cellular components by lysosomes is essential to maintain biological homeostasis. In mammals, three forms of autophagy, macroautophagy, microautophagy and chaperone-mediated autophagy (CMA), have been identified. Here, we showed a novel type of autophagy, in which RNA is taken up directly into lysosomes for degradation. This pathway, which we term RNautophagy, is ATP-dependent, and unlike CMA, is independent of HSPA8/Hsc70. LAMP2C, a lysosomal membrane protein, serves as a receptor for this pathway. The cytosolic tail of LAMP2C specifically binds to almost all total RNA derived from mouse brain. The cytosolic sequence of LAMP2C and its affinity for RNA are evolutionarily conserved from nematodes to humans. Our findings shed light on the mechanisms underlying RNA homeostasis in higher eukaryotes.
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