Journal
AUTOPHAGY
Volume 8, Issue 2, Pages 281-283Publisher
LANDES BIOSCIENCE
DOI: 10.4161/auto.8.2.18938
Keywords
neurodegeneration; Parkinson disease; Lewy bodies; alpha-synuclein; degradation; autophagy; lysosome; proteasome; in vivo; multiphoton imaging
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Progressive accumulation of alpha-synuclein is key to the pathology of many neurodegenerative diseases, including Parkinson disease and dementia with Lewy bodies. Increased intracellular levels of alpha-synuclein may be caused by enhanced expression or alterations in protein degradation pathways. Here we review our recent study showing that the ubiquitin-proteasome system and the autophagy-lysosomal pathway are differentially involved in alpha-synuclein's degradation in vivo. We discuss the key findings obtained with our novel in vivo approach and also present a model for the progression of protein aggregation and dysfunctional degradation in Parkinson disease.
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