Journal
AUTOPHAGY
Volume 8, Issue 4, Pages 692-693Publisher
LANDES BIOSCIENCE
DOI: 10.4161/auto.19305
Keywords
LRRK2; Parkinson disease; autophagy; calcium; NAADP; two-pore channel; lysosome
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Alterations in autophagy are thought to underlie various neurodegenerative diseases including Parkinson disease (PD). Previous studies have indicated that the PD gene leucine rich repeat kinase 2 (LRRK2) is involved in this process, but its mechanism of action has remained unknown. Our recent work describes how LRRK2 acts through calcium-mediated events originating from acidic stores to regulate autophagy and cell survival, which may give rise to novel therapeutic strategies.
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