Journal
AUTOPHAGY
Volume 8, Issue 5, Pages 715-716Publisher
LANDES BIOSCIENCE
DOI: 10.4161/auto.19920
Keywords
autophagy; cholesterol; lipids; lysosome; stress
Categories
Funding
- NIGMS NIH HHS [R01 GM053396] Funding Source: Medline
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Degradation in the lysosome/vacuole is not the final step of autophagy. In particular, for starvation-induced autophagy it is necessary to release the breakdown products back into the cytosol. However, some researchers ignore this last step and simply refer to the endpoint of autophagy as degradation, or perhaps even cargo delivery. In many cases this is not a serious issue; however, the analysis of autophagy's role in certain diseases makes clear that this can be a significant error.
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