Journal
AUTOPHAGY
Volume 8, Issue 4, Pages 707-708Publisher
LANDES BIOSCIENCE
DOI: 10.4161/auto.19627
Keywords
VPS34; PIK3C3; autophagy; endocytosis; PtdIns3K; PtdIns3P; liver; heart; cancer
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Funding
- NCI NIH HHS [R01 CA129536, R01 CA136754] Funding Source: Medline
- NIDDK NIH HHS [R01 DK062722] Funding Source: Medline
- NIGMS NIH HHS [R01 GM097355] Funding Source: Medline
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PIK3C3/Vps34 is the class III PtdIns3K that is evolutionarily conserved from yeast to mammals. Its central role in mammalian autophagy has been suggested through the use of pharmacological inhibitors and the study of its binding partners. However, the precise role of PIK3C3 in mammals is not clear. Using mouse strains that allow tissue-specific deletion of PIK3C3, we have described an essential role of PIK3C3 in regulating autophagy, and liver and heart function.
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