Journal
LIVER TRANSPLANTATION
Volume 7, Issue 11, Pages 937-942Publisher
WILEY
DOI: 10.1053/jlts.2001.27475
Keywords
-
Categories
Ask authors/readers for more resources
The clinical profile of neurotoxicity caused by immunosuppression has changed. When toxic levels are reached, both cyclosporine and tacrolimus may produce a clinical spectrum that varies from tremor and acute confusional state to status epilepticus; and major speech or language abnormalities. Coma has become an unusual manifestation. Magnetic resonance imaging has been better defined, and abnormalities may be more widespread than those in the posterior lobes. These white matter lesions are caused by vasogenic edema, but may lead to apoptosis an cytotoxic edema if exposure is prolonged. Recent evidence suggests inhibition of a drug-efflux: pump and dysfunction of the blood-brain barrier by enhanced nitric oxide production.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available