Journal
AUTOPHAGY
Volume 7, Issue 3, Pages 297-300Publisher
LANDES BIOSCIENCE
DOI: 10.4161/auto.7.3.14502
Keywords
Atg; autophagy-related; Cvt; cytoplasm to vacuole targeting; PAS; phagophore assembly site
Categories
Funding
- NIGMS NIH HHS [R01 GM053396] Funding Source: Medline
Ask authors/readers for more resources
Mitochondrial dysfunction has severe cellular consequences and is linked with neurodegenerative diseases and aging. Maintaining a healthy population of mitochondria is thus essential for proper cellular homeostasis. Several strategies have evolved to prevent and limit mitochondria damage, and macroautophagy plays a role in degrading superfluous or severely damaged mitochondria. Selective removal of mitochondria by autophagy (termed mitophagy) has been extensively studied recently in both yeast and mammalian cells. In this review, we summarize our current knowledge of mitophagy. We also compare the molecular process of mitophagy with other types of specific autophagic pathways and discuss its biological importance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available