Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 49, Issue 11, Pages 1479-1481Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.49.1479
Keywords
2-substituted chromone; 9(10 -> 20)-abeo-abietane; Chamaecyparis pisifera; Pinaceae; antibacterial activity; diterpene
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In the course of our research for biologically active constituents from coniferous plants, a chromone derivative (1) and an abietane derivative (2) were isolated along with several diterpenes from Chamaecyparis pisifera. Structures of the new compounds were determined to be 5,7-dihydroxy-2-(1-acetyl-2-methoxycarbonylethyl)-chromone and rel-(8R,10R,20S)-8,10,20-trihydroxy-9(10 --> 20)-abeo-abieta-9,13-dien-12-one by means of spectral methods including two-dimensional NMR experiments. Some of these abietane-type compounds isolated from this plants showed antibacterial activity against the gram-positive bacteria Staphylococcus aureus and Bacillus subtilis.
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