Journal
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
Volume 4, Issue 6, Pages 545-549Publisher
SPRINGER-VERLAG
DOI: 10.1007/s10024001-0085-3
Keywords
choroid plexus carcinoma; rhabdoid tumor; deletion of chromosome 22; monosomy 22; p53
Categories
Ask authors/readers for more resources
Five of six poorly differentiated choroid plexus carcinomas identified at our institution contained cells displaying a rhabdoid phenotype. Immunoperoxidase stains showed focal positivity for cytokeratin, epithelial membrane antigen, glial fibrillary acidic protein, S100, and vimentin. The MIB-1 proliferative index ranged from 7.0% to 27.1%. All six tumors were p53 positive. Only the one child with Li-Fraumeni syndrome had a p53 germline mutation. Electron microscopy verified choroid plexus differentiation and the co-existence of rhabdoid cells. Of the five studied, four had deletions of chromosome 22 [three with monosomy 22 and one with del(22)(q12)]. Thus, there was a phenotypic and genotypic overlap between choroid plexus carcinomas and rhabdoid tumors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available