Journal
AUTOPHAGY
Volume 7, Issue 10, Pages 1098-1107Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.7.10.15904
Keywords
GEC1; GABARAPL1; GABARAP; LC3; autophagy; cancer; neurodegenerative diseases; estrogens
Categories
Funding
- Ligue Contre le Cancer (Conference de Coordination Inter Regionale Grand Est), Comite du Doubs
- Ministere de l'Enseignement Superieur et de la Recherche (MESR)
- Region de Franche-Comte/Canceropole Grand-Est
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The GABARAPL1 (GABARAP-LIKE 1) gene was first described as an early estrogen-regulated gene that shares a high sequence homology with GABARAP and is thus a part of the GABARAP family. GABARAPL1, like GABARAP, interacts with the GABA A receptor and tubulin and promotes tubulin polymerization. The GABARAP family members (GABARAP, GABARAPL1 and GABARAPL2) and their close homologs (LC3 and Atg8) are not only involved in the transport of proteins or vesicles but are also implicated in various mechanisms such as autophagy, cell death, cell proliferation and tumor progression. However, despite these similarities, GABARAPL1 displays a complex regulation that is different from that of other GABARAP family members. Moreover, it presents a regulated tissue expression and is the most highly expressed gene among the family in the central nervous system. In this review article, we will outline the specific functions of this protein and also hypothesize about the roles that GABARAPL1 might have in several important biological processes such as cancer or neurodegenerative diseases.
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